Suffering is a reality of human existence from time immemorial, changing form and severity from one period, person, and location to another. The Scripture affirms this fact and presents God’s desire to alleviate human suffering in diverse forms; it also reveals God’s willingness to use human agents to achieve this alleviation. The incarnation story in the Gospel points in this direction, with Jesus generously setting the oppressed free and alleviating their sufferings. The paper uses a historical-grammatical method and argues that discipleship involves hospitality, which challenges transactional relationships and social hierarchies. In Luke 14:12- 15, Jesus passes on the teaching of hospitality without expecting recompense from the beneficiaries to those who would follow him and accept the kingdom character he offers. In this teaching, there is a clear intersection of discipleship and hospitality where Jesus encourages his audience and followers to improve the condition of the marginalised. The text, set within Luke’s broad Travel Narrative (9:51-19-27), is relevant to the African context of suffering, marked by poverty, disease, marginalisation, social injustice, civil unrest, and violence. Thus, Jesus’ teaching calls for a renewed theological reflection and practical response that motivates Christians to take responsibility for improving the condition of the marginalised. Significantly, Jesus redefines hospitality from the generally accepted perspective of familiar and social bonds to inviting those who cannot reciprocate, such as the poor and indigent community members. The paper recommends that individual Christians and the African church do more of this kind of discipleship as a redemptive response to suffering.