The paper focuses on the correlation between the transformational leadership practice demonstrated by the educational administrators at the Ghana private universities and the success of the mentorship and professional development programs. The study is thus a qualitativeresearch that examines how the major aspects of a transformational leader, which are vision articulation, inspirational motivation, intellectual stimulation, and individualized consideration, influence the mentoring structures and the production of professional growth among the academic and administrative personnel. Semi-structured interviews with university administrators, mentoring coordinators, and staff in the selected private universities provided the data, which was triangulated with institutional documents and other related literature published in 2022-2025. The results show that transformational leadership has a positive impact on the growth of mentoring engagement, staff motivation, professional competence, and development of collaborative and learning oriented institutional culture. The researchers highlight that the issue of effectiveness in institutional performance and sustainability depend on organized mentoring systems, leadership development programmes, and continuing capacity-building instruments.