Background: Hyperglycemia, a key risk factor for Type 2 Diabetes Mellitus (T2DM), has become a significant health concern globally, especially in urbanizing areas. Taxi drivers, with their sedentary work environment, long hours, and irregular eating habits, may be at higher risk for metabolic disorders such as hyperglycemia. This study aimed to evaluate the prevalence of hyperglycemia and identify associated risk factors among taxi drivers in Agblezaa-Teshie, Greater Accra, Ghana. Methods: A cross-sectional study was conducted among 133 active taxi drivers in the Teshie Agblezaa area. Fasting blood glucose levels were measured, and sociodemographic, lifestyle, and occupational data were collected using structured questionnaires. Results: The prevalence of hyperglycemia was found to be 24.1%, with older drivers (aged 50- 59 years) and those working longer hours (9-12 hours daily) exhibiting higher rates. Lifestyle factors such as sedentary behavior, poor dietary habits, work-related stress, and low physical activity were strongly associated with hyperglycemia. While the majority of drivers were aware of general health risks related to hyperglycemia, their knowledge of specific symptoms and prevention strategies was limited. Significant barriers to healthcare access included financial constraints, time limitations, and lack of health insurance. Conclusion: The study highlights a substantial burden of hyperglycemia among taxi drivers in Agblezaa-Teshie, driven by sedentary work, poor lifestyle choices, and limited healthcare access. Targeted health interventions, including regular glucose screenings, health education, and improved healthcare access, are urgently needed to address this public health concern.