This study investigated whether loan-loss provision and loan-to-deposit ratios serve as major determinants of the performance of deposit money banks in Nigeria via ex-post facto research design. Panel data were obtained from the annual reports and accounts of 14 listed deposit money banks from 2012-2023. Data obtained were analyzed via descriptive, diagnostic and inferential statistics. The fixed and random effects panel regression results revealed among others that while loan-to-deposit ratio(t-value = -2.22; p-value = 0.028 < 0.05%) significantly influence financial performance of deposit money banks, loan-loss provisions ratio (t-value = .55; p-value = 0.580 > 0.05%) was found to insignificantly affects financial performance of deposit money banks. Based on the findings, the study recommends adequate capital requirement that covers all anticipated inherent risks (loans) should be set as minimum before DMBs are given operating licenses. In addition, management of deposit money banks should be more equipped with the right skills, experience and knowledge in ensuring safe and smooth use of provisions of loans losses in their day-to-day operations. The study contributes to knowledge by establishing that while, loan-to-deposit ratio has significant effect on the performance of deposit money banks, loan-loss provisions ratio has insignificant effect on the performance of deposit money banks in Nigeria.