Detoxification, or detox, is the process by which the body removes harmful substances, such as toxins, xenobiotics, and waste products. Xenobiotics, including drugs, pollutants, and other foreign substances, pose a significant threat to human health. The liver plays a vital role in detoxifying these harmful compounds, protecting the body from their adverse effects. This seminar will delve into the liver's critical functions in xenobiotic detoxification, exploring the enzymatic pathways, transport mechanisms, and regulatory processes involved. Understanding the liver's role in detoxifying xenobiotics is essential for developing effective strategies to mitigate the adverse effects of these substances. This seminar aims to provide a comprehensive overview of the liver's detoxification mechanisms, highlighting their significance in maintaining human health and preventing disease.