Introduction: Antifungal resistance is one of the main problems that continue to challenge the healthcare section in a large part of the world particularly in Cameroon. The rapid increase rate of fungal community related infection of the skin and increase resistance to antifungal synthetic drugs has stimulated the need to research on new substances that can be used to solve this problem of resistance. This has been sparingly reported to the best of our knowledge. Objective: To evaluate the phytochemical and antifungal properties of Afrostyrax lepidophyllus, Monodora nyrisca and Xylopia aethiopica Sampling at Bamenda food-market on Trichophyton rubrum . Materiel and Methods: The experimental study was carried out from February 24th to march 25th 2022, in order to sought out new antifungal agents from spices, by assessing the antifungal property of Afrostyrax lepidophyllus (country onion), Xylopia aethiopica( bush pepper) and Monodora myristica (groundnut-spices) spices on Trichophyton rubrum. To identify the different compounds present in these spices, qualitative phytochemical screening was also carried out. This was accomplished by purchasing dried spices of Afrostyrax lepidophyllus, Xylopia aethiopica, and Monodora myristica from various locations in the Bamenda food market and aseptically grinding them into powder. The resulting powder underwent independent ethanolic and aqueous extraction processes. Results: The results showed that Trichophyton rubrum was sensitive to all aqueous extraction of the three spices using agar dilution technique after 48hrs of incubation at room temperature, while Trichophyton rubrum was sensitive only to alcoholic extract of Afrostyrax lepidophyllus under the same growth conditions of incubation. The phytochemical screening results of Afrostyrax lepidophyllus and Xylopia Aethiopica spices indicated the presence of alkaloids, flavonoids, Saponin, resins, tannins (except for Afrostyrax lepidophyllus) and the absence of glycosides in all the spices. Monodora myristica indicated the presence of saponin and flavonoids only. CONCLUSION: The objective of the study on the evaluation on the phytochemical and antifungal properties of Afrastyrax lepidophyllus, Xylopia aethiopica and Monodora myristica on Trichophyton rubrum, revealed sensitivity to the aqueous extracts of all the spices. The ethanolic extract of A lepidophyllus also revealed sensitivivity to T.rubrum. This proves that all the spices have antifungal properties and as such can be used as alternative treatment for fungal skin infection cause by T. rubrum.