This study investigated the effect of Zingiber officinale ethanol extract on neurological indices in male Wistar albino rats induced with inflammation. The study was laid out in a Complete Randomized Experimental Design (CRED). A total of five groups were assessed: Group A (Blank Control), Group B (Negative Control), Group C (Standard Control), Group D (Low-Dose Treated Group), and Group E (High-Dose Treated Group). Inflammatory induction led to significant reductions (p < 0.05) in the concentrations of key neurohormones including dopamine, serotonin, acetylcholine, and epinephrine in the negative control group. Specifically, dopamine and serotonin levels were markedly decreased in Group B (449  ± 0.001 pg/ml and 1.60 ± 0.001 μg/L, respectively) compared to Group A (653 ±  0.001 pg/ml and 5.21 ±  0.001 μg/L, respectively). Acetylcholine and epinephrine levels also declined significantly in the negative control group (5.16 ± 0.031 mm and 3.12 ± 0.004 pg/ml, respectively) relative to the blank control. Treatment with Z. officinale ethanol extract, particularly at the high dose (Group E), significantly restored neurohormonal levels. The highdose group showed values statistically similar (p > 0.05) to the blank control in dopamine (638 ± 0.000 pg/ml), serotonin (5.12 ± 0.003 μg/L), and acetylcholine (11.08 ± 0.013 mm), while moderate improvements were observed in epinephrine levels (7.91 ± 0.023 pg/ml). The findings suggest that Z. officinale ethanol extract exerts neuroprotective effects by enhancing neurotransmitter levels suppressed during inflammation, with the high dose showing the most significant efficacy.