The Nigeria brewery industry plays a significant role in the country‘s manufacturing and consumer goods sectors, contributing to employment, revenue generation and Gross Domestic Product (GDP). The study examined the effect of value chain management practices on organizational performance in the Nigeria Brewery Industry. The study adopted the cross sectional survey research design method to investigate the effect of value chain management practices on organizational performance in the Nigeria Brewery Industry. The population were restricted to individuals who possess direct involvement and expertise in Value Chain Management (VCM) in one (1) major brewery in Nigeria; Guinness Nigeria Plc Benin-City, Edo State. The total population of the study were 349 employees. The findings indicated that there was an overwhelming positivity among the variables: with inbound logistics and organizational performance, outbound logistics and organizational performance, all showed a significant effect on the dependent variable. The study concluded that efficient inbound logistics ensures that inputs and raw materials are available when needed, thereby minimizing production delays and resource wastage. It was therefore recommended that organizations should develop robust and reliable distribution channels that ensure timely delivery of goods to customers and retailers. Partnerships with reputable logistics service providers can enhance reach and efficiency.