The objective of this research is to explain the factors contributing to the obstinacy of marijuana against legal repression in Cameroon throughout the case study of Semi-Bantu people, by examining the cultural practices and beliefs shaping the relationship between cannabis and the concerned indigenous populations. The research design is explorative, using qualitative method of the research. Ethnography has provided Primary data through interviews and direct observation, using a containing open-ended questions Form. Because of the repression from the police about cannabis and ethical considerations, the researcher has avoided Focus groups discussions. Secondary data were provided by written sources and Internet. Data analysis consisted in Explanation, Comment, Comparison. Functionalism and Cultural Interpretative approaches have been exploited to explain facts. According to the Research findings, Cannabis resists to legal repressions because, it is a Culture Core, a cultural feature that is fundamental among Semi-Bantu people’s ways of making their living; including Food, Ethno medicine, Spirituality, Social Organization, and other domains of Semi-Bantu’s Ethno Science. Cannabis is embedded in Semi-Bantu’s traditions. The Government’s Law preventing people from Cannabis Use, is culturally incompatible or inappropriate. The Survival of Cannabis to Law is also due to its high prize in the black market, it provides much more than other Crops. As suggestion, Local cultural practices and beliefs should be taken into account before the implementation of any Policy. Failure in the application of that principle has caused the resistance from the concerned populations in Cameroon.