This study was centered on an Assessment of media channel mostly used in receiving information of tackle prostate cancer by South-East men. The major objective of the study was to find out the media channel mostly used by South-East Nigerian men, in accessing information to tackle prostate cancer. The study adopted social judgment theory. The study also adopted survey research method with questionnaire and interview as instruments for data collection. The sample size was made up of 385 respondents, out of a population of 5,068,566. Multi-stage sampling technique was adopted for the study. The major findings of the study showed that majority of men in South-East- Nigeria access more information to tackle prostate cancer through social media. It was also revealed that there is a high level of interest in getting more media information about tackle of prostate cancer. It was concluded that media campaign on tackle prostate cancer and sensitization of health benefits are serious campaigns on Social media. This is because of the high level of spread of the ailment and its deadly nature. It is therefore recommended that different media channels or platforms should constantly present and promote campaigns to tackle prostate cancer in our society and always present campaigns that will positively affect the health status of men in the country.